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USP9X deubiquitinates ITCH. 4 / 5
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"USP9X has been reported to simultaneously regulate endocytosis of the EGFR by deubiquitinating its endocytic adaptor Eps15 and ubiquitin ligase Itch in tumor cell lines (17, 18, 40)."
35389885
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"USP9X (FAM) deubiquitylates the autoubiquitylated E3 ligases Itch and SMURF1 and, thereby, increases their stability XREF_BIBR - XREF_BIBR."
24714733
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"USP9X has been shown to regulate EGFR endocytosis in tumor cell lines by deubiquitinating its endocytic adaptor Eps15 and ubiquitin ligase Itch [31]."
36653359
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"USP8 and USP9X deubiquitinate ITCH to induce ubiquitination and degradation of the anti-apoptotic protein c-FLIP, leading to apoptosis in glioblastoma [XREF_BIBR], or to anoikis in pancreatic ductal adenocarcinoma [XREF_BIBR]."
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