IndraLab

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Estrogen inhibits NLRP3. 19 / 19
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"Since the extracellular release of HSP27 is largely dependent on estrogen levels (Rayner et al., 2008; Rayner et al., 2009), we speculate that estrogen can inhibit the activation of NLRP3 inflammasome by promoting HSP27 secretion.Since NLRP3 inflammasome activation is regulated by many factors, the above-mentioned mechanisms may not be able to explain all of the details."
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"In fact, recent reports have demonstrated that estrogen therapies can trigger the protein unfolding response and inhibit the activation of NLRP3 inflammasomes in interim of COVID-19 infection [101] ."
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"Depletion of ovarian estrogen triggers excessive activation of the NLRP3 inflammasome, leading to osteoblast pyroptosis and the acceleration of bone resorption [26–28]."
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"For example, Melatonin suppressed OP triggered by estrogen deficiency by inactivating NLRP3 inflammasome [31]."
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"Estrogen downregulated NLRP3 inflammasome and reduced lipid accumulation in cardiomyocytes during stress."
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"This study was performed to identify whether NLRP3 inflammasome can be triggered by lipopolysaccharides (LPS) and adenosine triphos adenine (ATP), which are positively related with knee OA severity in joint-spaces, in human fibroblast like synoviocytes (FLS), and to identify whether estrogen would inhibit the activation of NLRP3 inflammasome."
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"These results indicated that melatonin ameliorates estrogen deficiency induced osteoporosis and impaired osteogenic differentiation potential by suppressing activation of the NLRP3 inflammasome via mediating the Wnt and beta-catenin pathway."
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"Estrogen and progestin directly inhibit NLRP3 inflammasome."
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"Both androgen and estrogen inhibit NLRP3 inflammasome by increasing ACE2 expression."
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"Estrogen inhibits the activation of complement cascade to inhibit NLRP3 inflammasome."
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"Estrogen inhibits P2X7R, thus suppressing the activation of NLRP3 inflammasome."
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"Moreover, estrogen reduces intestinal inflammation by activating NLRP3 inflammasomes [8], and therefore, the combined effects of decreased postpartum estrogen and gut microbiota imbalances potentially intensify the inflammatory response."
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"As noted previously, estrogen can inhibit the protective autophagy of tumors by regulating the NLRP3 inflammasome, ultimately inhibiting the progression of HCC (41)."
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"52 Female reproductive hormones, estrogen and progesterone, suppress inflammatory immune responses and NLRP3 inflammasome function."
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"Estrogen has been shown to reduce neuroinflammation by inhibiting the NLRP3 inflammasome, thereby exerting a beneficial effect on Parkinson’s disease ."
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"Emerging evidence has shown that estrogen can act as an inflammatory protective factor to suppress NLRP3 mediated neuroinflammation in the hippocampus."
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"21 Mechanistically, estrogen could suppress inflammation by inhibiting NF‐κB activity, NLRP3 inflammasome, and so forth."
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"But in the brain and in fibroblast like synoviocytes, estrogen inhibits activation of the NLRP3 inflammasome."
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"The expression of estrogen receptor β (ERβ) and NLRP3 were reported to be significantly downregulated in liver tissues of patients with HCC, and their expression levels were positively correlated; estrogen can inhibit HCC cell proliferation and metastasis by activating NLRP3 through the ERβ/mitogen-activated protein kinase (MAPK) pathway (80, 81)."
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