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COPS5 activates HTR6. 2 / 2
| 2

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"Moreover, the knockdown of Jab1 attenuated 5-HT 6 R agonist induced-Runx2 suppression as well as osteoblast differentiation as evidenced by ALP staining (XREF_FIG) and activity (F) and differentiation markers, ALP, OCN, and bone sialoprotein (BSP) (XREF_FIG)."

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"Our previous studies identified 5-HT 6 R associated partners such as Fyn, Jab1, and MAP1B which activate 5-HT 6 R function [XREF_BIBR XREF_BIBR XREF_BIBR], which are implicated in cognition, neurodevelopment, and neurodegeneration [XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR]."