IndraLab

Statements

USP47 decreases the amount of TP53. 2 / 2
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"USP47 knockdown led to an increased binding of RPS2 to MDM2, inhibiting MDM2 activity and upregulating p53 levels under ribosomal stress, thereby inhibiting cell proliferation, colony formation, and tumor progression (Cho et al., 2020)."
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"Knockdown of USP7 or USP47 increased the protein levels of p53 and the mRNA levels of CDKN1A, a p53 target gene encoding p21 protein, without affecting p53 gene expression (Figs."
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