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TNFAIP3 inhibits pyroptosis. 8 / 8
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"Apoptosis and pyroptosis of NP cells increased gradually treated with LPS for 12 h , 24 h , and 48 h. Differently , the level of mitophagy increased first and then decreased , and was the highest at LPS treatment for 12 h. Overexpression or knockdown of A20 in NP cells revealed that A20 attenuated the pyroptosis , apoptosis , and production of inflammatory cytokines of NP cells induced by LPS , while A20 sponsored mitophagy , reduced ROS production and collapse of mitochondrial membrane potential ( DeltaPsim ) ."
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"In this part, we obtained 1 downregulated pyroptosis-related gene, Adipoq, and 12 upregulated pyroptosis-related genes, Trem2, Aoah, Tlr2, Ccr5, Tnfaip3, Tlr9, Tnf, Zbp1, Nlrp3, Clec5a, Il1b and Mefv."
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"It has been validated that TNFAIP3 can restrict pyroptosis induced by NLRP3 inflammasome activation independent of its inhibitory effect on the NF‐κB pathway."
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"A20 also has the ability to inhibit pyroptosis in a mechanism that is dependent on active Casp1 , thereby restoring the IL-1beta production process Therefore , in the TNF-alpha inflammatory pathway , which is upstream of the inflammatory response , A20 can target RIPK1 for proteasomal degradation , thus protecting cells from NF-kappaB activation and the subsequent production of pro-inflammatory factors ."
| PMC
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"A20 has the ability to inhibit pyroptosis through a mechanism that is dependent on Casp1 , thereby preventing the maturation of pro-IL-1beta , but the exact mechanism remains unknown [ 20 ] ( Fig. 3d ) ."
| PMC
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"Here , we demonstrated that A20 promoted mitophagy , attenuated pyroptosis , and inhibited the degradation of the extracellular matrix , consequently significantly ameliorating disc degeneration ."
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"Mechanistically , A20 reduces pyroptosis and further suppresses cellular mTOR activity ."
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"IL‐1β positive granules were also elevated after Tnfaip3 knockout, especially scattering in the cytoplasm of fibroblasts (Figure 4N).2.5 TNFAIP3 Inhibits Pyroptosis by the Ubiquitination of NEK7."
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