IndraLab

Statements

TNFAIP3 inhibits pyroptosis. 5 / 5
| 5
eidos
"Mechanistically , A20 reduces pyroptosis and further suppresses cellular mTOR activity ."
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eidos
"Here , we demonstrated that A20 promoted mitophagy , attenuated pyroptosis , and inhibited the degradation of the extracellular matrix , consequently significantly ameliorating disc degeneration ."
36583816
eidos
"A20 also has the ability to inhibit pyroptosis in a mechanism that is dependent on active Casp1 , thereby restoring the IL-1beta production process Therefore , in the TNF-alpha inflammatory pathway , which is upstream of the inflammatory response , A20 can target RIPK1 for proteasomal degradation , thus protecting cells from NF-kappaB activation and the subsequent production of pro-inflammatory factors ."
| PMC
eidos
"A20 has the ability to inhibit pyroptosis through a mechanism that is dependent on Casp1 , thereby preventing the maturation of pro-IL-1beta , but the exact mechanism remains unknown [ 20 ] ( Fig. 3d ) ."
| PMC
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"Apoptosis and pyroptosis of NP cells increased gradually treated with LPS for 12 h , 24 h , and 48 h. Differently , the level of mitophagy increased first and then decreased , and was the highest at LPS treatment for 12 h. Overexpression or knockdown of A20 in NP cells revealed that A20 attenuated the pyroptosis , apoptosis , and production of inflammatory cytokines of NP cells induced by LPS , while A20 sponsored mitophagy , reduced ROS production and collapse of mitochondrial membrane potential ( DeltaPsim ) ."
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