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Celastrol inhibits RELA. 7 / 7
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"Nevertheless, celastrol reversed the decrease of cytoplasmic p65 protein and the increase of nuclear p65 protein induced by AOM and DSS."
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"It was observed that celastrol suppressed constitutively p65 and IKK, which may led to the inhibition of phosphorylation of p65 and IkBa, respectively XREF_BIBR."
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"Celastrol also inhibited poly (I : C)-induced p65 DNA binding activity, as determined by EMSA (XREF_FIG)."
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"The results showed that Celastrol attenuated the proliferation of RA-FLS , and inhibited phosphorylation of IKK and IkappaBalpha as well as down-regulated NF-kappaB p65 [ 86 ] ."
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"Celastrol (12) at 3 or 6 µM and pristimerin (13) at 6 µM reduced the IL-1α-induced increase in the nuclear RelA protein (Figure 5B,E)."
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"We found that celastrol induced accumulation of IKBalpha through impeding the phosphorylation of IKBalpha , leading to reduction of p65 , revealing that celastrol inhibited NF-kappaB pathway activation in TNBC cells ."
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"Pre-loading celastrol for 30 min could inhibit the actions of MEK1, ERK1, NF-kappaB (p65), and STAT1, but not p38 (XREF_FIG)."
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