IndraLab

Statements


USP48 deubiquitinates RELA. 3 / 4
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"As p65 is also a direct interactor and target of USP48 [17], the CSN complex promotes USP48-mediated deubiquitination of p65 and its stabilization on chromatin."

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"USP48 interacts with the transcription factor NF-kappaB, deubiquitinates NF-kappaB subunit p65 and promotes its stability and activation, and up-regulates NF-kappaB target genes known to inhibit synaptogenesis."

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"USP48 deubiquitinates p65 and promotes its activation."