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OTULIN activates RNF31. 2 / 2
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"Tbk1 deficiency unleashes cell death in the fetal liver that is driven by TNFR1 and the kinase activity of RIPK1, 73 , 122 whereas embryonic lethality caused by Otulin inactivation (or by loss of the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"OTULIN hyper-phosphorylation promotes necroptosis by locking ring finger protein 31 (RNF31, also known as HOIP) away from the cylindromatosis (CYLD) complex, resulting in altered receptor interacting serine/threonine kinase 1 (RIPK1) ubiquitination."
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