IndraLab
Statements
Ceftriaxone inhibits KCNH2. 3 / 3
|
3
reach
"In the laboratory, we found that, in combination, lansoprazole and ceftriaxone block the hERG channel up to 57.6%, corresponding with an APD70 increase of 50 ms. At these higher lansoprazole concentrations, it is likely that, if treated as a single entity, the combination would not have received regulatory approval."
reach
"This finding is in agreement with recent evidence showing that lansoprazole in combination with ceftriaxone carries a risk of QTc interval prolongation, as it has been demonstrated that ceftriaxone + lansoprazole can significantly block the hERG channel and inhibit I (− 57.6%) [35, 36]."