IndraLab

Statements

TNF phosphorylates INSR. 9 / 9
1 | 4 4
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"some of the insulin resistance induced by the p60 TNF Moreover, staurosporin, a non specific inhibitor of pro- receptor; treatment of hepatoma cells and 3T3-L1 adipo- tein kinase C, did not abrogate t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
8899294
reach
"In addition, the inhibition of IL-1β and TNFα in REC grown in high glucose decreased phosphorylated IRS-1 and cleaved caspase 3 levels, while increasing phosphorylation of the insulin receptor and Akt."
30116147
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"Tumor necrosis factor alpha (TNFalpha) or chronic hyperinsulinemia that induce insulin resistance trigger increased Ser/Thr phosphorylation of the insulin receptor (IR) and of its major insulin receptor substrates, IRS-1 and IRS-2."
9368067
sparser
"TNF-α promotes inhibitory phosphorylation of insulin receptor substrate (IRS) proteins, and enhances ceramide synthesis, adipocyte lipolysis and inhibits PPARγ expression ( xref ; xref )."
35021057
sparser
"Although the precise mechanism of obesity-related insulin sensitivity remains unclear, it appears that within adipose tissue, TNFα phosphorylates and deactivates insulin receptor (IR) and insulin receptor substrate 1 (IRS-1) [ xref , xref ]."
31207311
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"This is true for TNF-alpha, which acts on the insulin receptor and prevents the dephosphorylation of insulin receptor substrates, thus blocking receptor signaling and preventing glucose entry into the cell (insulin resistance)."
24527464
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"Furthermore, TNF-α induced serine phosphorylation of IR and IRS-1, and these effects were completely precluded by pretreatment with inhibitors of p38 MAPK."
30429793
bel
"Analysis of intestinal tissue in TNF-alpha-treated hamsters indicated impaired phosphorylation of insulin receptor-beta, insulin receptor substrate-1, Akt, and Shc and increased phosphorylation of p38, extracellular signal-related kinase-1/2, and Jun NH(2)-terminal kinase."
17259391
sparser
"In the same adipocytes or surrounding skeletal muscle cells, TNF-α may increase serine phosphorylation of the insulin receptor and also of IRS-1 and possibly other proteins that mediate intracellular[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12505756