IndraLab

Statements

USP12 leads to the dephosphorylation of AR on S215. 3 / 3
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"In agreement with the above result, knockdown of Usp12 in LNCaP cells increased both AR S213 phosphorylation and AR turnover."
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"As such, overexpressing Usp12 inhibits AR S213 phosphorylation resulting in increased AR stability and transcriptional activity."
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"Our data demonstrates that Usp12 increases the levels of PHLPP and PHLPPL that in turn decreases the active pAkt pool and inhibits AR S213 phosphorylation by Akt."
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