IndraLab

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Sulforaphane inhibits RELA. 8 / 8
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"Furthermore, SFN treatment suppressed nuclear localization of p65."
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"To determine whether SFN suppresses MAPKs and p65 activation to exert its effects on the pro inflammatory markers, we measured the phosphorylation of MAPKs and NF-kappaB p65 proteins."
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"In Fig. 2A we have shown that sulforaphane inhibits the canonical NF-κB p65 subunit from translocating into the nucleus."
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"As shown in Fig. 5, SFN reduced the nuclear localization of p65 induced by TNF-alpha."
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"In addition, SFN has been shown to prevent the degradation of IkappaB-alpha and nuclear localization of p65 in bovine aortic endothelial cells, presumably via reduction of intracellular glutathione le[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To study whether SFN was also able to inhibit nuclear localization of p65 after TNF-alpha treatment, immunocytochemical staining of p65 was performed."
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"The western blotting results showed that SFN visibly impaired p65 production, whereas SFN enhanced p50 secretion in moDCs (XREF_FIG)."
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"In xref we have shown that sulforaphane inhibits the canonical NF-κB p65 subunit from translocating into the nucleus."
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