IndraLab
Statements
EIF3F bound to EIF3D, EIF3H, EIF3G, EIF3J, EIF3B, EIF3E, EIF3I, EIF3A, EIF3M, EIF3C, EIF3K, and EIF3L activates RPS17 bound to RPSA, RPS2, RPS4Y1, RPS3, RPS12, RPS19, RPS27, RPS9, RPS5, RPS10, RPS20, RPS3A, RPS7, RPS8, RPS15A, RPS16, RPS14, RPS23, RPS18, RPS29, RPS13, RPS11, RPS4X, RPS6, RPS15, RPS24, RPS25, RPS26, RPS28, FAU, RPS27A, RPS21, RPS27L, and RPS4Y2. 1 / 1
1
|
"EIF3 binds 40S and inhibits the association of 60S. Structural analysis suggests that eIF3 performs this scaffolding function by binding to the 40S subunit on its solvent-exposed surface rather than on its interface with the 60S subunit, where the decoding sites exist. This location of eIF3 seems ideally suited for its other proposed regulatory functions, including reinitiating translation on polycistronic mRNAs and acting as a receptor for protein kinases that control protein synthesis."