IndraLab

Statements

UCHL1 activates cellular senescence. 6 / 6
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"Taken together, these findings indicated that UCHL1, negatively regulated by Sp1, promoted H O -mediated cell injury, oxidative stress, apoptosis and senescence, and modulated NF-κB signaling in HEI-OC1 cells."
36761006
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"In this context, PEM treatment may induce senescence in NSCLC cells XREF_BIBR, however, it is possible that UCHL1 levels could be increased in senescent cells, thereby modifying the senescence process XREF_BIBR."
32483437
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"Overexpression of UCHL1 was found to induce senescence, likely due to increased production of p14ARF, p53, p27KIP1 and decreased MDM2 levels [XREF_BIBR]."
25543668
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"This effect of UCHL1 on NF-κB signaling was abrogated by Sp1 overexpression.In conclusion, the present study suggested that UCHL1, negatively regulated by Sp1, could promote H O -mediated cell injury, oxidative stress, apoptosis and senescence and inhibit NF-κB signaling in an in vitro model of ARHL."
36761006
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"In addition, UCHL1 overexpression enhanced cell viability and promoted oxidative damage, apoptosis and senescence in H 2 O 2 -induced HEI-OC1 cells."
36761006
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"Indeed, we could observe more cells with an increased level of SA-beta-gal in cells overexpressing UCHL1 compared to the respective mock control cells, suggesting that the overexpression of UCHL1 leads to the induction of cellular senescence in LNCaP prostate cancer cells."
21999842