IndraLab
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UCHL1 activates cellular senescence. 4 / 4
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"In addition, UCHL1 overexpression enhanced cell viability and promoted oxidative damage, apoptosis and senescence in H 2 O 2 -induced HEI-OC1 cells."
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"Indeed, we could observe more cells with an increased level of SA-beta-gal in cells overexpressing UCHL1 compared to the respective mock control cells, suggesting that the overexpression of UCHL1 leads to the induction of cellular senescence in LNCaP prostate cancer cells."
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"Overexpression of UCHL1 was found to induce senescence, likely due to increased production of p14ARF, p53, p27KIP1 and decreased MDM2 levels [XREF_BIBR]."
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"In this context, PEM treatment may induce senescence in NSCLC cells XREF_BIBR, however, it is possible that UCHL1 levels could be increased in senescent cells, thereby modifying the senescence process XREF_BIBR."