IndraLab

Statements

Brefeldin A inhibits STING1. 4 / 4
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"First, Brefeldin A, known to cause disassembly of the Golgi complex [66], blocked MITA trafficking, indicating that Golgi apparatuses are involved in the translocation of MITA."
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"Brefeldin A, but not chloroquine, blocked STING trafficking, indicating that STING locates from the ER via the Golgi to vesicles in the perinuclear region (XREF_SUPPLEMENTARY)."
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"First, Brefeldin A, known to cause disassembly of the Golgi complex XREF_BIBR, blocked MITA trafficking, indicating that Golgi apparatuses are involved in the translocation of MITA."
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"Another V-ATPase inhibitor Concanamycin A (ConA) also blocked STING degradation, while Brefeldin A (BFA, blocks ER exit) blocked STING activation (no slower migrating band) and degradation (XREF_FIG, substantial STING degradation is not expected in the absent of trafficking)."
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