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Brefeldin A inhibits STING1. 7 / 7
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"However, treatment of these fibroblasts with brefeldin A, an inhibitor of COPI vesicle formation and Golgi-to-ER transport (59), blocks these effects, suggesting that a complete inhibition of the COPI-dependent transport disrupts STING accumulation and activation at the Golgi."
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"Brefeldin A, but not chloroquine, blocked STING trafficking, indicating that STING locates from the ER via the Golgi to vesicles in the perinuclear region (XREF_SUPPLEMENTARY)."
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"First, Brefeldin A, known to cause disassembly of the Golgi complex XREF_BIBR, blocked MITA trafficking, indicating that Golgi apparatuses are involved in the translocation of MITA."
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"Blocking STING trafficking with the ADP ribose factor and GTP enzyme inhibitor brefeldin A can block STING signaling pathway activation."
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"28 , 36 Brefeldin A inhibits STING1 accumulation in ERGICs, 11 whereas H-151 limits the palmitoylation of STING1 to prevent the localization of STING1 at the Golgi apparatus 37 ( Figure 2 G)."
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"Another V-ATPase inhibitor Concanamycin A (ConA) also blocked STING degradation, while Brefeldin A (BFA, blocks ER exit) blocked STING activation (no slower migrating band) and degradation (XREF_FIG, substantial STING degradation is not expected in the absent of trafficking)."
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"To investigate where the interaction between TRIM10 and STING occurs, we treated peritoneal macrophages with brefeldin A (BFA), a specific inhibitor of protein trafficking, which blocks STING traffick[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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