IndraLab

Statements

OTUB1 activates RAS. 5 / 6
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"OTUB1 triggers RAS activity and downstream signaling."
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"This further confirms that OTUB1 up-regulation may contribute to the development of different tumor types harboring wt RAS."
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"Here we found that OTUB1 promotes tumorigenic transformation of wt RAS cells by triggering the RAS and MAPK pathway."
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"OTUB1 promotes RAS activation and tumorigenesis in wild-type RAS cells."
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"Consistent with the observation that OTUB1 inhibits RAS ubiquitination, analysis of RAS localization revealed that OTUB1 overexpression augmented the presence of RAS proteins on the plasma membrane (Fig XREF_FIG E and F; XREF_SUPPLEMENTARY)."
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