IndraLab
Statements
OTULIN activates Proteasome. 2 / 2
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2
reach
"OTULIN deficiency leads to excessive linear ubiquitination on proteasome subunits, which disrupts proteasome assembly and function.41 Therefore, Ty56 phosphorylation of OTULIN may increase its DUB activity on the proteasome, potentiating the ubiquitin-proteasome system (UPS) activity that may have profound effects on oncogenesis.42Cylindromatosis protein (CYLD), another DUB, is recruited to LUBAC via the adaptor SPATA2, which binds to both CYLD and HOIP via PUB-PIM interactions."