IndraLab

Statements


USP15 increases the amount of E6. 4 / 4
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"Overexpression of USP15 resulted in increased levels of the E6 protein, and the small interfering RNA mediated knockdown of USP15 decreased E6 protein levels."

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"Our results indicate that USP15 could increase the level of HPV16 E6 by inhibiting E6 degradation."

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"Moreover, siRNA-mediated knockdown of USP15 and USP11 independently reduced E6 and E7 protein levels, respectively, underscoring the therapeutic potential of targeting both viral and host-driven mechanisms."

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"Knockdown of USP15 by siRNA approach demonstrated that silencing of USP15 decreases the protein levels of E6 significantly."