IndraLab

Statements

Resveratrol inhibits MAP3K7. 6 / 6
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"In vitro and in vivo data showed that resveratrol inhibited TAK1 activation, inflammation and fibrosis in experimental pneumoconiosis."
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"To achieve pharmacological TAK1 inhibition, we virtually screened out a natural product resveratrol, which targeted TAK1 at both N161 and A107 residues, and significantly inhibited TAK1 activation to attenuate inflammation and fibrosis in vitro."
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"Resveratrol limited the activation of TAK1 and its downstream signaling pathway, including the degradation of IkappaBalpha, the activation of NF-kappaB P65 and the phosphorylation of P38 and JNK."
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"Consistent with the virtual screening data, our in vitro data demonstrated that the screened resveratrol effectively inhibited TAK1 activation, inflammatory response in cultured alveolar macrophage NR8383 cells with silica exposure and fibrotic response in cultured lung fibroblast WI-38 cells with TGF-beta stimulation in vitro."
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"Interestingly , in vitro experiments showed that resveratrol targeted TAK1 at both N161 and A107 residues and significantly inhibited TAK1 activation to alleviate inflammation and lung fibrosis ( Li et al ., 2017 ) ."
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"Furthermore, TAK1 inhibition by resveratrol may also pave the way for treatment of other lung diseases, which are characterized with pulmonary inflammation and fibrosis."
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