IndraLab

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Resveratrol inhibits MAP3K7. 11 / 11
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"To investigate whether resveratrol can inhibit TAK1 activity in gouty arthritis mice, the protein levels of TAK1 and p-TAK1 were analyzed using western blotting."
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"Furthermore, TAK1 inhibition by resveratrol may also pave the way for treatment of other lung diseases, which are characterized with pulmonary inflammation and fibrosis."
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"A previous study showed that resveratrol can significantly inhibit TAK1 activation by targeting at both the N161 and A107 residues [ 12 ]."
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"In vitro and in vivo data showed that resveratrol inhibited TAK1 activation, inflammation and fibrosis in experimental pneumoconiosis."
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"In osteoclasts, resveratrol inhibits osteoclastogenesis by suppressing the MAPK and TRAF6/TAK1 pathways while also reducing oxidative stress and inflammation through the suppression of the ROS/HIF-1α and Nox4/NF-κB pathways, respectively."
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"Consistent with the virtual screening data, our in vitro data demonstrated that the screened resveratrol effectively inhibited TAK1 activation, inflammatory response in cultured alveolar macrophage NR8383 cells with silica exposure and fibrotic response in cultured lung fibroblast WI-38 cells with TGF-beta stimulation in vitro."
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"To achieve pharmacological TAK1 inhibition, we virtually screened out a natural product resveratrol, which targeted TAK1 at both N161 and A107 residues, and significantly inhibited TAK1 activation to attenuate inflammation and fibrosis in vitro."
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"Interestingly , in vitro experiments showed that resveratrol targeted TAK1 at both N161 and A107 residues and significantly inhibited TAK1 activation to alleviate inflammation and lung fibrosis ( Li et al ., 2017 ) ."
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"These data imply that resveratrol can efficiently prevent TAK1 activation and attenuate the MSU crystal-induced inflammatory response.To test the effects of resveratrol on MSU crystal-induced murine p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Resveratrol inhibits the activation of the TAK1, MAPK, and NF-κB pathways, thereby suppressing the production of pro-inflammatory cytokines such as IL-6 and TNF-α in Mtb-infected macrophages (147)."
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"In MSU crystal-induced THP-1 cells and arthritis mice, resveratrol could inhibit the active form of TAK1 (p-TAK1, T187)."
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