IndraLab

Statements

STUB1 ubiquitinates KCNH2. 3 / 3
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reach
"The CHIP ablation effect could be attributed to CHIP dependent ubiquitination of hERG, since siCHIP reduced ouabain induced polyubiquitination of wt-hERG (XREF_FIG, lanes 3 and 6, and Supplemental Figure S5D)."
24152733
sparser
"The CHIP ablation effect could be attributed to CHIP-dependent ubiquitination of hERG, since siCHIP reduced ouabain-induced polyubiquitination of wt-hERG ( xref , lanes 3 and 6, and Supplemental Figure S5D)."
24152733
reach
"The documented CHIP dependent polyubiquitination of hERG, regardless of whether structural destabilization was attained by missense mutations or extracellular and intracellular K + depletion, suggests that the conformational defect recognized by the QC converges onto to the cytosolic domains."
24152733