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Lopinavir inhibits KCNH2. 3 / 3
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"Lopinavir, remdesivir, and chloroquine were also shown to have low toxic dose threshold in humans, inhibit human ether-a-go-go-related gene (hERG) and induce hepatotoxicity (Table 5)."
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"Drug induced QT prolongation is usually caused by block of human ether-a-go-go-related gene (HERG) potassium channels, and we showed that lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent block of HERG channels heterologously expressed in HEK293 cells in vitro."
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"In vitro, lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent hERG channel blockade."
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