IndraLab

Statements

Lopinavir inhibits KCNH2. 4 / 4
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"Theoretical models suggest that the degree of hERG blockade given by lopinavir/ritonavir is expected to produce a prolongation of QTc interval of <5 ms. High-grade atrio-ventricular blocks are additional side effects, and multiple drug interactions are possible due to the inhibition of CYP3A."
32820084
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"Lopinavir/ritonavir blocks hERG, calcium, and late sodium at similar potencies and was included as a balanced blocker."
30447156
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"In vitro, lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent hERG channel blockade."
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"Drug induced QT prolongation is usually caused by block of human ether-a-go-go-related gene (HERG) potassium channels, and we showed that lopinavir, nelfinavir, ritonavir, and saquinavir caused dose dependent block of HERG channels heterologously expressed in HEK293 cells in vitro."
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