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IGF1R binds SLC2A1. 11 / 11
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"IGF-1R enters astrocytes by binding to astrocyte glucose transporter 1 (GLUT1) via the low-density lipoprotein receptor-related protein-1 (LRP1) and scaffolding protein GIPC PDZ domain containing family, member 1 (GIPC1) (Fig. 2)."
36691085
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"It has been reported that in astrocytes, LRP1 together with the scaffolding protein GIPC (GAIP-interacting protein, C terminus) mediate the molecular interaction between insulin-like growth factor 1 receptor (IGF1-R) and GLUT1."
29914093
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"In IRA beta cells, either Glut-1 or Glut-2 associated with IRA or IGF-IR, that association was stimuli-independent."
25797178
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"Expression of IGF-1R and GLUT1 were associated with poor overall survival in multivariate analysis, and therefore appear to be possible interesting biomarkers of radiation resistance."
28716107
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"Expression of IGF-1R and GLUT1 could be associated with poor prognosis, and therefore appear to be possible interesting biomarkers of radiation resistance."
28716107
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"Analysis of underlying mechanisms indicated that IGF-IR interacts with glucose transporter 1 (GLUT1), the main facilitative glucose transporter in astrocytes, through a mechanism involving interactions with the scaffolding protein GIPC and the multicargo transporter LRP1 to retain GLUT1 inside the cell."
27462832
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"Firstly, we observed that GluT1 and IGF-IR interact, as determined by co-immunoprecipitation, and confirmed by proximity ligation assays ( Fernandez et al., 2017 )."
28859884
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"In order to analyze the possible role of IR isoforms on the glucose availability in the process of beta cell proliferation we studied the glucose uptake in the four cell lines studied as well as the a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
25797178
sparser
"In IRA beta cells, either Glut-1 or Glut-2 associated with IRA or IGF-IR, that association was stimuli-independent."
25797178
sparser
"Specifically, disrupting GluT1 interactions with IGF-IR may result in increased glucose uptake, while reinforcing their interaction will result in the opposite effect."
28859884
sparser
"In Panel C, it can be seen that LRP1, together with GIPC (GAIP-interacting protein, C terminus), mediate the molecular interaction between IGF1-R and GLUT1, with GLUT1 being retained inside the cell."
29914093