IndraLab

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OTUD6B deubiquitinates IRF3. 4 / 4
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"These findings uncover that human OTUD6B can deubiquitinate and stabilize IRF3 and enhance type I IFN antiviral immunity."
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"Our results showed that overexpression of OTUD6B, and not defective OTUD6B-C57S, dramatically attenuated the ubiquitination levels of exogenously expressed IRF3, demonstrating that OTUD6B does reduce IRF3 ubiquitination levels and its deubiquitinase activity is critical (Fig. 5C)."
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"Human OTUD6B positively regulates type I IFN antiviral innate immune responses by deubiquitinating and stabilizing IRF3."
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"In contrast, OTUD6B knockdown enhanced IRF3 ubiquitination modification levels (Fig. 5D)."
37650650