IndraLab

Statements

KCNA2 binds SIGMAR1. 7 / 7
| 7
sparser
"The activation of Sigma-1 receptor enhances the trafficking of Kv1.2 channels to the PM in both the nucleus accumbens (NAc) and the prefrontal cortex (PFC), which is proposed to be mediated by Sigma-1 receptor-Kv1.2 interaction."
31178723
sparser
"x channel family; however, the biophysical nature of the interaction between Sig-1R and Kv1.2 has not been elucidated."
31222975
sparser
"These data suggest that Kvβ2 occludes the interaction of Sig-1R with Kv1.2, and that E102 may be a residue critical for Sig-1R modulation of Kv1.2."
31222975
sparser
"The Sig-1R-Kv1.2 interaction has been shown to shape neuronal and behavioral responses to cocaine [ xref ]."
26869505
sparser
"More importantly, Sig-1R interacts with Kv1.2 in baseline conditions to influence bimodal activation gating."
31222975
sparser
"In this report, cocaine exposure induces Sig-1R translocation to the plasma membrane and shapes intrinsic plasticity via the persistent association of Sig-1R and Kv1.2 in the nucleus accumbens shell medium spiny neuron [ xref ]."
26869505
sparser
"Cocaine increases the interaction between Sig-1R and Kv1.2 likely in the plasma membrane due to an increased Kv1.2 in the plasma membrane as a consequence of the activation and translocation of Sig-1R from the ER to the plasma membrane."
27088037