IndraLab

Statements

SIGMAR1 binds KCNA2. 5 / 5
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"Cocaine increases the interaction between Sig-1R and Kv1.2 likely in the plasma membrane due to an increased Kv1.2 in the plasma membrane as a consequence of the activation and translocation of Sig-1R from the ER to the plasma membrane."
27088037
sparser
"The Sig-1R-Kv1.2 interaction has been shown to shape neuronal and behavioral responses to cocaine [ xref ]."
26869505
sparser
"In this report, cocaine exposure induces Sig-1R translocation to the plasma membrane and shapes intrinsic plasticity via the persistent association of Sig-1R and Kv1.2 in the nucleus accumbens shell medium spiny neuron [ xref ]."
26869505
sparser
"The activation of Sigma-1 receptor enhances the trafficking of Kv1.2 channels to the PM in both the nucleus accumbens (NAc) and the prefrontal cortex (PFC), which is proposed to be mediated by Sigma-1 receptor-Kv1.2 interaction."
31178723
sparser
"In motor neurons, Sig-1R colocalizes with Kv1.2, and Sig-1R-Kv1.2 interactions determine neuronal and behavioral responses to cocaine [ xref , xref ]."
36768323