IndraLab

Statements

OTUB1 inhibits Proteasome. 3 / 3
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"OTUB1, which is overexpressed in multiple human cancers, directly interacts with SLC7A11 to remove its ubiquitination marks, preventing proteasome-mediated degradation and increasing its stability, thus inhibiting the activation of ferroptosis."
39769177
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"As shown in XREF_FIG, the steady-state levels of SLC7A11 in OTUB1 depleted cells were significantly restored upon treatment with the MG132 proteasome inhibitor (lane 4 vs. lane 2), indicating that OTUB1 depletion promotes SLC7A11 degradation in a proteasome dependent manner."
30709928
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"This suggests that OTUB1 inhibits proteasome‐dependent degradation of CCN6."
37608493