IndraLab

Statements

OTUD5 increases the amount of PTEN. 2 / 2
| 2
reach
"In addition to inhibiting USP20, a recent study confirmed that 160 nM GSK2643943A also has an inhibitory effect on another DUB, ovarian tumor protease deubiquitinase 5 (OTUD5), which can increase the [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
36423672
reach
"We further detected the protein levels of PTEN in A549 and HCI-H460 cells with another Western blot assay and uncovered that overexpression of OTUD5 promoted the protein level of PTEN, while PTEN protein levels were further increased on treatment with MG132 (a proteasome inhibitor) (p < 0.05, Figure 3C), indicating that OTUD5 may regulate PTEN expression through the proteasome pathway."
35765958