IndraLab

Statements


PLC inhibits KCNH2. 2 / 2
| 2

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"The human ether-a-go-go related gene (HERG) K channel, which is known to be modulated by PIP , is inhibited by cholesterol enrichment via increased phospholipase C (PLCβ1) expression [16]."

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"These results suggest that cholesterol enrichment inhibits either endogenous MIC current or exogenous HERG current via the membrane PIP 2 depletion by PLC activation."