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Piperazine activates KCNH2. 1 / 1

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"XREF_BIBR, XREF_BIBR Replacement of the N-methylpiperazine moiety in 6 with a morpholine ring (compound 10a) was beneficial in reducing affinity for hERG, consistent with our hypothesis that hERG affinity is driven by the presence of a piperazine basic center."

23043539

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IndraLab

Statements

Piperazine activates KCNH2. 1 / 1

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