IndraLab

Statements

HCN4 activates cell differentiation. 5 / 5
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"We conclude that HCN2 and HCN4 channel isoforms, but not HCN1 and HCN3, promote the differentiation of PC12 cells toward sympathetic neurons."
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"In this study, the underlying mechanism responsible for this differentiation may involve upregulation of the HCN4 promoter by TBX18, which indirectly increases the expression of HCN4 and enhances the efficiency of the differentiation of ADSCs into pacemaker like cells."
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"It may therefore be speculated that high levels of Nkx2.5 in EPCs after knockdown of Gata4 downregulate Hcn4 expression to promote their differentiation into atrial myocytes."
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"It may be hypothesized that the reduced enrichment of H3K9me2 in the HCN4 promoter region led to changes in chromosome state, promoted the binding of Tbx18 to the HCN4 promoter region and increased HCN4 transcription, which promoted cell differentiation to pacemaker-like cells."
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"Our previous study found that transfection of HCN4 gene can promote the differentiation of BMSCs into cardiomyoid cells [27]."
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