IndraLab

Statements

HCN4 activates cell differentiation. 3 / 3
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"In this study, the underlying mechanism responsible for this differentiation may involve upregulation of the HCN4 promoter by TBX18, which indirectly increases the expression of HCN4 and enhances the efficiency of the differentiation of ADSCs into pacemaker like cells."
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"We conclude that HCN2 and HCN4 channel isoforms, but not HCN1 and HCN3, promote the differentiation of PC12 cells toward sympathetic neurons."
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"It may therefore be speculated that high levels of Nkx2.5 in EPCs after knockdown of Gata4 downregulate Hcn4 expression to promote their differentiation into atrial myocytes."
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