IndraLab

Statements

MAF binds OTUB1. 21 / 21
4 | 8 9
sparser
"AVT interferes with the interaction between Otub1 and c-Maf to increase c-Maf polyubiquitination."
33627137
biogrid
No evidence text available
32842143
sparser
"AVT was identified from the Otub1/c-Maf system, while Otub1 interacts with c-Maf and prevents its polyubiquitination as its deubiquitinase, therefore, we wondered whether AVT can inhibit Otub1 activity toward c-Maf ubiquitination."
33627137
sparser
"In order to explore this concept, we performed a c-Maf-recognition element-driven luciferase-based screen against FDA-approved drugs and natural products, from which the generic cardiac glycoside lanatoside C (LanC) is found to prevent c-Maf de-ubiquitination and induces its degradation by disrupting the interaction of Otub1 and c-Maf."
32842143
sparser
"Because Otub1 interacts with c-Maf thus preventing its ubiquitination, we next wondered whether AVT interfered with this interaction between Otub1 and c-Maf."
33627137
sparser
"It is essential for Otub1 to engage with c-Maf before preventing c-Maf polyubiquitination and degradation via the ubiquitin-proteasomal pathway, however, AVT can disrupt this interaction between Otub1 and c-Maf, which further abolishes the deubiquitinating activity of Otub1 towards c-Maf."
33627137
sparser
"Lanatoside C (LanC) is an inhibitor of OTUB1 and can inhibit Multiple Myeloma tumor growth through disrupting the interaction of OTUB1 and c-Maf [ xref ]."
38539203
sparser
"AVT disrupts the interaction between OTUB1 and the oncogenic transcript factor c-Maf, leading to c-Maf proteasome degradation and induced myeloma cell apoptosis [ xref ]."
39562545
reach
"In order to explore this concept, we performed a c-Maf-recognition element driven luciferase based screen against FDA approved drugs and natural products, from which the generic cardiac glycoside lanatoside C (LanC) is found to prevent c-Maf de-ubiquitination and induces its degradation by disrupting the interaction of Otub1 and c-Maf."
32842143
reach
"AVT was identified from the Otub1 and c-Maf system, while Otub1 interacts with c-Maf and prevents its polyubiquitination as its deubiquitinase, therefore, we wondered whether AVT can inhibit Otub1 activity toward c-Maf ubiquitination."
33627137
biogrid
No evidence text available
32842143
biogrid
No evidence text available
32842143
sparser
"Disrupting the interaction of OTUB1 and c-Maf led to c-Maf degradation and c-Maf-expressing multiple myeloma cell apoptosis [ xref ]."
40381229
sparser
"In a study by Xu et al. on multiple myeloma cell lines, Lanatoside C was found to increase K48-linked polyubiquitination of c-Maf , thereby disrupting the Otub1–c-Maf interaction."
41107785
biogrid
No evidence text available
33627137
reach
"Lanatoside C (LanC) is an inhibitor of OTUB1 and can inhibit Multiple Myeloma tumor growth through disrupting the interaction of OTUB1 and c-Maf [14]."
38539203
reach
"AVT disrupts the interaction of Otub1 and c-Maf thus inhibiting Otub1 activity and leading to c-Maf polyubiquitination and subsequent degradation in proteasomes."
33627137
reach
"AVT interferes with the interaction between Otub1 and c-Maf to increase c-Maf polyubiquitination."
33627137
reach
"Because Otub1 interacts with c-Maf thus preventing its ubiquitination, we next wondered whether AVT interfered with this interaction between Otub1 and c-Maf."
33627137
reach
"The above study has demonstrated that AVT could disrupt the interaction between Otub1 and c-Maf therefore inducing c-Maf degradation in proteasomes and MM cell apoptosis."
33627137
reach
"It is essential for Otub1 to engage with c-Maf before preventing c-Maf polyubiquitination and degradation via the ubiquitin-proteasomal pathway, however, AVT can disrupt this interaction between Otub1 and c-Maf, which further abolishes the deubiquitinating activity of Otub1 towards c-Maf."
33627137