IndraLab

Statements

COPS5 increases the amount of CDKN1B. 10 / 11
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"MIF inhibits JAB1-induced JNK and AP-1 activity and JAB1-dependent cell-cycle regulation by increasing p27Kip1 expression through stabilization of p27Kip1 protein."
22959722
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"SNU478 and HuCCT-1 cells exhibited profound Jab1 knockdown and increased p27 expression by Jab1-specific siRNA transfection."
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"In the HuCCT-1 mouse xenograft model, stable knockdown of Jab1 by shRNA also showed anti-proliferative effects in vivo, with decreased Ki-67 expression and AKT phosphorylation and increased Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and p27 expression."
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"Jab1 silencing by siRNA increases p27 expression in BTC cells."
30282449
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"Our results also showed that Jab1 silencing by siRNA increased p27 expression in six of eight BTC cell lines (Fig. 1B)."
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"Furthermore, we found that downregulation of Jab1 induces the cell cycle arrest at G1 phase and upregulated the expression of p27, p53 and Bax gene."
31345154
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"MIF-(50-65) and its variant bound to the MIF binding protein JAB1 and enhanced cellular levels of p27Kip1."
12796500
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"Jab1 negatively regulates expression of the cell cycle inhibitor cyclin dependent kinase inhibitor 1B (P27) through binding and targeting P27 for ubiquitination and degradation."
32456285
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"Conversely, down-regulation of JAB1 by short interfering RNA substantially increased p27 expression and inhibited progression from G (1) to S phase of the cell cycle."
16951171
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"For example, SC deletion of nuclear Jun activation domain binding protein 1 (Jab1) impairs radial sorting by regulating the levels of p27Kip1, which in turn promotes SC exit from the cell cycle and differentiation."
25921593