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UCHL1 activates necroptotic process. 5 / 7
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"In summary, five of the abovementioned genes (UCHL1, TRADD, H2AC6, VDAC3, JMJD7-PLA2G4B) promote necroptosis and necroptosis-independent cell death, while the remaining three genes (TFAF2, DAPK1, and RBCK1) have roles in protecting cells from necroptosis.To better evaluate the effect of the eight necroptosis-related genes in the prognostic model in COAD, we evaluated the expression levels of the eight necroptosis-related genes between the low-risk group and the high-risk group."
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"Unlike in apoptosis, HtrA2 and Omi did not cleave another protease, ubiquitin C-terminal hydrolase (UCH-L1) during TNF induced necroptosis, but rather induced monoubiquitination indicative for UCH-L1 activation."
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"Incremental UCHL1 further enhances the activation of the RIPK3/MLKL pathway and promotes podocyte necroptosis."
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"UCHL1 was also found to be involved in the regulation of TNF-induced podocyte necroptosis [ 5 ]."
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"Since UCHL1 mainly regulates the HG-induced podocyte necroptosis, to confirm whether RIPK1 and RIPK3 levels decrease due to a protein metabolism disorder, we treated podocytes with 200 μg/mL cyclohexi[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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