IndraLab

Statements


USP7 inhibits UHRF1. 3 / 7
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"However, active USP7 completely abolished the autoubiquitinylation of UHRF1 by removal of ubiquitin adducts."

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"Second, we hypothesize that HAUSP directly inhibits the E3 ubiquitin ligase activity of UHRF1."

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"USP7 prevents UHRF1 from autoubiquitinylation in vitro and regulates its stability in vivo."