IndraLab

Statements

USP7 inhibits UHRF1. 6 / 10
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"In addition, the phosphorylation of UHRF1 ser-652 reduces the interaction between UHRF1 and deubiquitinase USP7, which promotes the degradation of UHRF1 protein [38]."
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"Second, we hypothesize that HAUSP directly inhibits the E3 ubiquitin ligase activity of UHRF1."
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"USP7 could also prevent autoubiquitinylation of UHRF1, thus plays an important general role in epigenetic regulation ( Nicholson & Suresh Kumar, 2011 )."
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"USP7 prevents UHRF1 from autoubiquitinylation in vitro and regulates its stability in vivo."
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"HDAC1 and HAUSP can prevent UHRF1 and DNMT1 from acetylation and ubiquitination for degradation mediated by Tip60 during S phase when the abundance of Tip60 is relatively low."
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"However, active USP7 completely abolished the autoubiquitinylation of UHRF1 by removal of ubiquitin adducts."
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