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SHOX2 decreases the amount of HCN4. 2 / 2

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"Shox2 -/- embryos have a reduced SAN size and exhibit increased expression of Nkx2.5, Cx40, and Cx43, and decreased expression of Hcn4, Tbx3, and Isl1 in the SAN primordium and show cardiac arrhythmias and embryonic lethality at day E11.5 [XREF_BIBR]."

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"Shox2 deficient embryos have markedly decreased SAN, dysfunctional cardiac pacemaker activity and reduced Hcn4 expression."

30906456

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IndraLab

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SHOX2 decreases the amount of HCN4. 2 / 2

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