IndraLab

Statements

Zinc atom inhibits IKBKB. 4 / 4
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sparser
"For example, the IκB kinase (IKK) members IKKα and IKKβ are inhibited by zinc, albeit at high concentrations of ∼0.5 µM ( xref )."
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reach
"Related to this, our group has discovered that transport of Zn through the Zn transporter ZIP8 into the cytosol functions to inhibit IKKbeta in monocytes and lung tissue, thereby controlling the extent of NF-kappaB activation and inflammation in response to sepsis XREF_BIBR, XREF_BIBR."
24732911
sparser
"Very recently, direct inhibition of IKKβ [IκB (inhibitor of NF-κB) kinase β] by zinc was reported [ xref ], while others have also shown that zinc indirectly inhibits IKKβ via cGMP-dependent activation of PKA (protein kinase A) [ xref ]."
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sparser
"To understand whether zinc selectively inhibits IKKα and/or IKKβ, we exposed IKKβ (−/−) mouse embryonic fibroblast (MEFs) to IL-1β and evaluated NF-κB-mediated function."
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