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USP47 inhibits NLRP3. 2 / 2
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"The deubiquitinase USP47, which specifically inhibits NLRP3 activation, was also able to inhibit NLRP3 activation, thereby ameliorating seizures in rats [36]."
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"miR-29c reduces the inflammatory response of microglia by modulating the NLRP3 inflammasome [188], miR-17-5p ameliorated NLRP3 inflammasome activation-mediated hypoxic–ischemic brain injury in rat [189], and miR-138-5p overexpression in epileptic neurons inhibits NLRP3 by directly binding with ubiquitin-specific peptidase 47 (USP47), a positive regulator of NLRP3 [190]."
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