IndraLab

Statements

STAM binds USP8. 13 / 14
4 1 | 5 3
hprd
No evidence text available
10982817
reach
"Hrs is constitutively associated with STAM, which in turn can bind to the deubiquitinating enzyme UBPY [38], implying that the correlation between E3 ligase POSH and UBPY (or unidentified DUB) might m[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16084064
biogrid
No evidence text available
20736164
sparser
"Hrs is constitutively associated with STAM, which in turn can bind to the deubiquitinating enzyme UBPY [38] , implying that the correlation between E3 ligase POSH and UBPY (or unidentified DUB) might[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16084064
reach
"In contrast, stability of the UBPY binding partner STAM is dramatically compromised in UBPY knockdown cells."
16520378
biogrid
No evidence text available
16520378
biogrid
No evidence text available
10982817
sparser
"It has been shown previously that a subset of SH3 domains bind ubiquitin ( xref , xref ), and a recent study using NMR titration experiments showed that the SH3 domain of STAM does in fact bind ubiquitin, and that this interaction can be competed off by USP8 binding to the SH3 domain of STAM ( xref )."
24151880
reach
"USP8 can form complexes with the ESCRT-0 subunit STAM on endosomes, stimulating de-ubiquitination of EGFR on endosomes, and promoting EGFR endosome-to-plasma membrane recycling [XREF_BIBR]."
29543760
reach
"Both AMSH and Usp8 bind to ESCRT-0 protein STAM through a non canonical SH3 binding motif, and with their MIT-domain to several CHMP proteins of the ESCRT-III machinery [30,37,39,40]."
22800866
sparser
"That STAMs could be components of a larger complex of a ubiquitin machinery is suggested by a study of Kato et al. [31] , showing that the deubiquitinating enzyme UBPY binds to the SH3 domain of STAM[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
11728436
reach
"The Adenosine A2 receptor is deubiquitinated by USP4; the ubiquitination status and trafficking of the EGFR growth factor receptor is regulated by the USP8 and STAM complex; the beta2-AR undergoes increased agonist stimulated ubiquitination, lysosomal trafficking, and degradation after knockdown of USPs 20 and 33."
21898592
biogrid
No evidence text available
20736164