IndraLab

Statements


IFN-I activates USP18. 4 / 4
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"11 Moreover, infection with S. typhimurium enhances IFN-I signaling and inflammatory response in Usp18 lty9 mice."

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"Both ISG15 and USP18 are induced by IFN-I and are essential for a balanced IFN response [25,26] ."

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"Both Usp18 and Isg15 genes are known to be strongly induced by IFN-I, genotoxic stress, and viral infection ( Farrell et al., 1979 )."

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"USP18 is transcriptionally induced by IFN-I and restrains global ISGylation by de-ISGylating substrates and also by inhibiting IFN-I signaling."