IndraLab

Statements

USP15 inhibits immune response. 4 / 4
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"Together, these findings suggest that USP15 inhibition may not only promote cancer cell apoptosis but also boost T cell mediated anti-tumor immunity."
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"For example, USP3, USP25, and USP18 played a positive regulation of the antiviral immune response [ 5–8 ], while USP5, USP4, USP13, USP15, USP14, USP2b, and USP19 negatively regulated antiviral immune[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2."
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"It is thus possible that inhibition of USP15, along with targeting immunosuppressive regulators of the tumor microenvironment, may induce strong antitumor immunity."
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