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BAP1 deubiquitinates Histone. 3 / 3
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"BRCA1 associated protein 1 (BAP1) is a ubiquitin C-terminal hydrolase that deubiquitinates histone H2AK119ub and other proteins and regulates the expression of multiple genes."
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"Mechanistically, BAP1 deubiquitinates histone 2AK119-ub1 (H2AK119-ub1), an epigenetic mark that represses gene expression and can have long-lasting effects on transcription."
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"Recent studies indicated epigenetic modifications as a result of deubiquitinating the mono-ubiquitinated H2AK119 histone by the hyperactivated BAP1/ASXL1 is one of the main drivers of the transcriptio[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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