IndraLab

Statements

USP3 deubiquitinates AR. 3 / 3
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"USP3 is also recruited by a novel lncRNA, AC092894.1, to promote AR (androgen receptor) deubiquitination and, subsequently, chemosensitivity to oxaliplatin[87]."
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"USP3 promotes transcription of RASGRP3 by deubiquitinating and stabilizing the transcription factor AR, and up-regulation of RASGRP3 increases CRC sensitivity to oxaliplatin [69]."
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"AC092894.1 serves as a scaffold molecule, enabling the deubiquitination of the androgen receptor (AR) by USP3, fostering the transcription of RASGRP3, and subsequently activating the MAPK signaling pathway, which augments oxaliplatin-induced apoptosis [73]."
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