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USP4 ubiquitinates IRF3. 2 / 2
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"In colon cancer, a deubiquitinating enzyme USP4 suppressed anti-tumor immune responses by deubiquitinating TRAF6 and IRF3, hindering the nuclear localization of the latter protein and thus inhibiting cellular interferon responses and antigen presentation (Zhou et al., 2024)."
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"The results indicated that USP4 suppresses the nuclear localization of IRF3 by deubiquitinating IRF3 in CRC cells.It has been reported that USP4 interacted with and deubiquitinates TRAF6 [ 25 ], which[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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