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UCHL3 activates KITLG. 4 / 4
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"We further demonstrate that UCHL3 upregulates the levels of SCF beta-TrCP substrates including IFN-I receptor IFNAR1, which enhances IFN-I mediated signaling pathway and antiviral activity."
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"Thus, our findings identify a novel in vivo substrate of UCHL3, and reveal a novel deneddylation regulation by UCHL3.It is interesting that UCHL3 controls the activity of cellular SCF beta and TrCP co[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we reveal that UCHL3 increases levels of SCF beta-TrCP substrates and enhances IFN-I mediated signaling and antiviral activity."
28583475
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"Moreover, we find that UCHL3 upregulates levels of SCF beta-TrCP substrates including IFN-I receptor IFNAR1, thereby enhancing IFN-I mediated signaling and antiviral activity."
28583475