IndraLab

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USP13 increases the amount of HMGB1. 4 / 4
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"In addition, the level of HMGB1 protein was significantly increased by USP13 overexpression and decreased by shUSP13 or Spautin-1 treatment, showing that HMGB1 levels are regulated by the deubiquitinase USP13."
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"Knockdown of USP13 expression by shUSP13 plasmid or inhibition of USP13 activity by Spautin-1 treatment decreased the stability of HMGB1 protein (Fig. 4D and E), demonstrating that USP13 regulates HMGB1 protein levels."
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"HMGB1 secretion was promoted by USP13 overexpression in a dose-dependent manner (Fig. 6A)."
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"Collectively, USP13 positively regulates HMGB1 secretion."
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