IndraLab

Statements

OTUB1 activates signal transduction. 5 / 5
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"Besides, when we blocked PI3K/AKT and/or MEK/ERK signaling by its specific inhibitor MK2206 and PD98059, the promotive effect of OTUB1-induced malignant behavior of HCC cells was also significantly reversed (Fig. 6d–q), demonstrating that OTUB1 performed the tumor-enhanced effects by effectively activating the AKT and ERK signaling pathway."
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"OTUB1 also inhibits DNA damage repair and promotes transforming growth factor-β signaling pathway independently of its DUB activity (12, 17)."
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"Finally, new research has discovered that OTUB1 enhances the activity of the FGFR2 signaling pathway by stabilizing FGFR2 and preventing its degradation."
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"The results were consolidated with the previous results, which further support the hypothesis that OTUB1 promotes the development of BLCA by mediating the β-catenin/RIPK3/MLKL signaling pathway."
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"OTUB1 Promotes Glioblastoma Growth by Inhibiting the JAK2/STAT1 Signaling Pathway."
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