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STAMBPL1 deubiquitinates SESN2. 4 / 4
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"To test whether STAMBPL1 or STAMBP plays the dominant role in deubiquitinating Sestrin2 and regulating mTORC1 signaling, we knocked out STAMBPL1 on its own or in combination with STAMBP knockdown."
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"Interestingly, Wang et al. reported that gastric cancer and colorectal cancer downregulate an E3 ubiquitin ligase RING finger protein 167 (RNF167) and upregulate a deubiquitinase STAMBPL1 that can prevent the ubiquitination of Sestrin2, decrease Sestrin2-GATOR2 interaction and increase mTORC1 signaling [119]."
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"Deficiency of STAMBPL1 promoted Sestrin2 ubiquitination ( Figures 2 E and S3 H–S3J), prevented lysosomal localization of mTORC1 upon amino acid sufficiency and suppressed mTORC1 activity ( Figures 2 F[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These results indicate that STAMBPL1 plays a major role in deubiquitinating Sestrin2."
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