IndraLab

Statements

USP13 decreases the amount of HMOX1. 3 / 3
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"Overexpression of USP13 reduced HMOX1 protein levels in lung fibroblast cells, suggesting that modulation of USP13 levels may affect oxidative stress."
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"Knockdown of USP13 by siRNA increased HMOX1 levels in lung fibroblast cells (Mrc5) and epithelial cells (A549 and BEAS-2B) (Fig. 2B, D, E), while HMOX1 levels were decreased in V5-tagged USP13-overexpressed Mrc5 cells (Fig. 2C), indicating that USP13 regulates HMOX1 levels in lung cells."
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"Knockdown of USP13 increased HMOX1 basal levels but did not rescue the HMOX1 reduction by TGF-β1 (Fig. 2B)."
34032995