IndraLab

Statements

USP4 inhibits pathway. 3 / 3
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"In contrast, a number of studies have described a tumor suppressive role of USP4 in certain cancers, including esophageal cancer, lung cancer, and head and neck cancer (HNSCC) [ xref – xref ]; For example, USP4 inhibits the NF-κB pathway by deubiquitinating RIP1 and TRAF4/6 in HNSCC and lung cancer, respectively [ xref , xref ]."
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"While prior research has established the involvement of autophagy in ferroptosis, our study provides mechanistic insights into how USP4 inhibits this pathway by stabilizing A2AR."
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"A study demonstrates that USP4 inhibits this pathway by deubiquitinating the polyubiquitin chain from Dvl, resulting in inhibiting of Wnt signal and decreased osteoblast differentiation and mineralization [ xref ]."
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