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Cardenolide inhibits JAK1. 2 / 2
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"Thus, cardenolides affect JAK1/STATs signalling mainly through diminishing JAK1 protein levels.This cardenolide-induced JAK1 diminishment/downregulation was also examined using a different coronavirus[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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eidos
"Our finding that cardenolides caused JAK1 diminishment via activation of NEDD4 suppress coronaviral replication bolsters that the NEDD4 associated JAK1 degradation is a candidate subject for the development of a novel PROTAC ; and therapeutic applications could be explored based on the property of JAK1 diminishment / inhibition of the cardenolides as antivirals ."
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