IndraLab

Statements

FASN binds USP2. 11 / 11
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reach
"For example, USP-2 interacts and stabilizes fatty acid synthase which is overexpressed in prostate cancer cells (Graner et al., 2004) or causes murine double minute 2 (MDM2) accumulation and enhance M[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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sparser
"Among these, USP2 interacts with FASN and promotes its protein stability by reducing the ubiquitination level of FASN in prostate cancer [ xref ]."
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No evidence text available
15050917
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15050917
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"For example, USP2 interacts and stabilizes fatty acid synthase [8], MDM2 [21], MDMX [22], Cyclin D1 [23], Aurora-A [24], Smad4 [25], and β-catenin [26]."
37628997
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No evidence text available
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15050917
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22370483
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"USP2 interacts with FASN in the mouse liver, human hepatic cancer, and HepG2 cells, and subsequently prevents the ubiquitination-dependent digestion of FASN [ xref , xref ]."
36834633
sparser
"Conversely, binding O-linked N-acetylglucosamine moieties to FASN interrupts USP2-FASN interactions, followed by attenuation of FASN-mediated lipogenesis in the liver [ xref ]."
36834633